Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial. Email: on: Shapiro J, van Lanschot JJ, Hulshof MC, et al. Cheung Kung-Hai Professor in Gastrointestinal Surgery Chief, Division of Esophageal and Upper Gastrointestinal Surgery, Department of Surgery, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China. These included positions previously associated with colorectal cancer, aging, and ancestry, “suggesting a role for genetic variation in contributing to DNA methylation differences in AA right colon,” the investigators say.Correspondence to: Professor Simon Law, MBBChir., MA, MS, FRCSEd, FCSHK, FHKAM, FACS. “One or more of these factors, or others that were not measured, may be linked to differential methylation in the right compared with left colon,” the editorialists write.Įven so, among the Black patients, almost 70% of differentially methylated positions in the right colon were hypermethylated, compared to less than half in the left colon. These included positions previously associated with colorectal cancer, aging, and ancestry, “suggesting a role for genetic variation in contributing to DNA methylation differences in AA right colon,” the investigators say. “One or more of these factors, or others that were not measured, may be linked to differential methylation in the right compared with left colon,” the editorialists write.Įven so, among the Black patients, almost 70% of differentially methylated positions in the right colon were hypermethylated, compared to less than half in the left colon. In addition, the study included more Black women than White women (67% vs 58%), and body mass indexes were higher for Black patients than White patients (31.36 kg/m 2 vs 28.29 kg/m 2). A higher proportion of Black patients smoked (37.5% vs 15%), and Black patients were younger (median age, 55.5 years, vs 61.7 years). Some differences between the Black patients and the White patients in the study could explain the methylation differences, they point out. However, “it is not clear if the higher epigenetic aging measured using the Horvath clock…directly translates to a higher risk of colorectal cancer,” they note. ![]() If these findings are “corroborated in African Americans in future studies, these results could potentially explain racial differences in the site predilection of colorectal cancers,”said Amit Joshi, MBBS, PhD, and Andrew Chan, MD, gastrointestinal molecular epidemiologists at Harvard University, Boston, Massachusetts, in an accompanying editorial. “Side-specific colonic epigenetic aging may be a promising marker to guide interventions to reduce CRC burden,” they suggest. “Our results provide biological plausibility for the observed relative preponderance of right colon cancer and younger age of onset in African Americans as compared to European Americans,” comment the investigators, led by Matthew Devall, PhD, a research associate at the Center for Public Health Genomics at the University of Virginia, Charlottesville, Virginia. A unique pattern of DNA hypermethylation was found in the right colon of Black patients.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |